4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity

Three new 4-phenylcoumarins, mesuaferlinns A–C (1–3), together with ten other known 4–13, were isolated from the branches and leaves of Mesua ferrea Linn. (Clusiaceae). The structure compounds 1–3 determined on basis spectroscopic methods including extensive analysis NMR mass data. Ten 4-phenylcoumarins tested for their cytochrome P450 family 1 enzymes (CYP1A1, CYP1A2, CYP1B1) inhibitory effects. Compounds 5 10 found to be most potent two CYP1B1 inhibitors viabilities values 56.64% 47.46%, respectively.